Description
Product Characteristics: In a study identifying genes in rat that are upregulated in response to nerve damage, a gene which is highly expressed in ganglia and in the central nervous system was found. The protein encoded by the rat gene contains both a zinc finger and a RING finger. Synonyms: Polyclonal ZNRF1 antibody, Anti-ZNRF1 antibody, zinc and ring finger 1 antibody, DKFZp434E229 antibody, FLJ14846 antibody, MGC15430 antibody, NIN283 antibody.
Target Information: This gene encodes an E3 ubiquitin-protein ligase that plays a role in neural-cell differentiation. Overexpression of this gene causes neurite-like elongation. The encoded protein contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification, and in synaptic vessicle membranes in neurons. [provided by RefSeq, Feb 2012]